Transparency

Science & Limits

What ASTRA Health simulates, which real NASA science it relies on as context, and which rules are demonstration choices. Nothing on this page turns a demonstration rule into a clinical limit or a NASA-approved procedure.

Simulated data

Synthetic values produced for the demonstration. Not measured on any person.

Heart rate, SpO₂ and temperature streams, signal quality, dropouts
Confirmation reading and ground acknowledgement

Real scientific data & evidence

Official NASA documents and public datasets, shown with source, link and limitations. Context only.

NASA HRP evidence reports — cardiovascular, hypoxia, medical capability
NASA OSDR OSD-575 — Inspiration4 serum cardiovascular biomarker panel

Demonstration rules

Thresholds, rules, checklists and timings written by the team. Provisional, not clinically validated, not NASA-approved.

Demo reference ranges, caution bands, plausibility limits, analysis rules, reliability score
Medical-support escalation rules and safety checklists
Earth–Mars delay 3–22 min, 30 s transmission, 2 min ground handling

Real scientific evidence · official sources

NASA Human Research Program — evidence library

Real scientific data & evidence

Official HRP evidence reports and risk pages on the risks ASTRA Health relates to. They are shown as scientific context with their source, link and limitations. ASTRA Health does not derive any threshold from them and does not present any of its checklists as NASA-approved.

Real scientific data & evidenceCardiovascularHRP Evidence Report

Evidence Report: Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Source:: NASA Human Research Program — Human Health and Countermeasures Element · Lyndon B. Johnson Space Center
Authors:: Lee SMC, Saha J, Charvat J, Suresh R, Lytle JR, Blattnig S, Laurie SS, Macias BR; Approved for public release: December 15, 2022

Evidence report (PDF, HRR)HRR risk page NASA risk overview

Official risk statement (verbatim)
“Given exposure to the spaceflight environment can contribute to cardiovascular deconditioning, dysfunction, and remodeling, there is a possibility that crews will experience impaired performance and adverse cardiovascular health outcomes that necessitate intervention during and after spaceflight and planetary operations.”
HRR risk page — Risk Statement

Key points (verbatim quotes)

“Development of dysrhythmias and venous thromboembolism (VTE), which has been reported recently, are the primary concerns during a spaceflight mission.”— Evidence report — Executive Summary
“…while there have been anecdotal reports and some documented cases of cardiac dysrhythmias during and after spaceflight, it is inconclusive whether spaceflight exposure causes or increases the frequency of these.”— Evidence report — Executive Summary
“Orthostatic intolerance after short- and long-duration spaceflight in low Earth orbit (LEO) is well-documented and is considered the primary risk during re-exposure to acceleration, including re-entry and landing on Earth.”— Evidence report — Executive Summary
“Cardiovascular disease (CVD) is considered the primary long-term health risk and concern for flight certification, especially for long-duration missions beyond LEO when exposure to space radiation will be greatest.”— Evidence report — Executive Summary

How ASTRA Health uses it

Scientific context for why ASTRA Health monitors heart rate and treats a sustained change as an event that needs attention. No heart-rate limit, alarm level or rule in the application is taken from this report.

No threshold derived

Related official records

Limitations

The report itself states that it is inconclusive whether spaceflight causes or increases cardiac dysrhythmias.
It is a review of research evidence approved for public release in December 2022 — not an operational procedure, a medical standard or an alarm specification.
ASTRA Health only simulates heart rate: dysrhythmias, venous thromboembolism and orthostatic intolerance cannot be detected from its signals.

Links and quotes verified against the official source on 2026-11-15.

Real scientific data & evidenceHypoxiaHRP Evidence Report

Evidence Report: Risk of Reduced Crew Health and Performance Due to Decompression Sickness and Hypoxia

Source:: NASA Human Research Program · Lyndon B. Johnson Space Center
Authors:: Garbino A, Norcross JR; Approved for public release: October 31, 2023

Evidence report (PDF, HRR)HRR risk page (Hypoxia)NASA risk overview

Official risk statement (verbatim)
“Given that future human exploration missions require robust, flexible Extravehicular Activity (EVA) architecture protocols that include the use of a reduced pressure cabin atmosphere enabling staged denitrogenation, there is a possibility that this atmosphere could result in compromised health and performance to the crewmember due to exposure to mild hypobaric hypoxia.”
HRR risk page — Risk Statement

Key points (verbatim quotes)

“In addition to hypobaric hypoxia associated with staged denitrogenation, there are additional factors that can result in hypoxic exposure to the crewmember such as cabin depressurization, Environmental Control and Life Support System (ECLSS) failure, toxic exposure or crewmember illness/injury.”— HRR risk page — Notes
“Although severe hypoxia is a risk during spaceflight due to a failure in pressure control or oxygen regulation, the focus of this risk and this evidence report will be on the risk of mild hypoxia associated with staged dinitrogenation [sic] … Standards, requirements, and hazard controls for severe hypoxia are covered elsewhere in the program.”— Evidence report — Hypoxia section
“The exploration atmosphere (8.2 psia/34% O2) was selected by the Exploration Atmospheres Working Group (EAWG) because it was considered to be a mildly hypoxic atmosphere with acceptable flammability risk and low O2 prebreathe (PB) overhead…”— HRR risk page — HSRB State of Knowledge

How ASTRA Health uses it

Scientific context for why ASTRA Health monitors oxygen saturation (SpO₂) and why a falling SpO₂ deserves attention. The application's SpO₂ demo ranges are not taken from this report.

No threshold derived

Related official records

Limitations

The report focuses on mild hypobaric hypoxia from the reduced-pressure exploration atmosphere and on decompression sickness; it states that standards for severe hypoxia are covered elsewhere in the program.
ASTRA Health does not use it as a source of pulse-oximetry limits; the application's SpO₂ ranges remain provisional demonstration values.
A single simulated finger SpO₂ stream cannot distinguish between the causes listed by NASA (atmosphere, depressurization, life-support failure, illness or injury).

Links and quotes verified against the official source on 2026-11-15.

Real scientific data & evidenceMedical capabilityHRP Evidence Report

Evidence Report: Risk of Adverse Health Outcomes and Decrements in Performance due to In-Flight Medical Conditions

Source:: NASA Human Research Program — Exploration Medical Capabilities (ExMC) Element · Lyndon B. Johnson Space Center
Authors:: Antonsen E, et al.; Approved for public release: May 8, 2017

Evidence report (PDF, HRR)HRR risk page (Medical Conditions)NTRS record 20170004604

Official risk statement (verbatim)
“Given that medical conditions will occur during human spaceflight missions, there is a possibility of adverse health outcomes & decrements in performance during these missions and for long term health.”
HRR risk page — Risk Statement

Key points (verbatim quotes)

“…communication with the ground will be limited in the best of circumstances by latency secondary to distance, with delays of up to 50 minutes for round trip communications near Mars (Hamilton et al. 2008; Baisden et al. 2008).”— Evidence report — Communication, Telemetry, and Data Constraints
“…available bandwidth for deep-space communications is likely to be severely limited, restricting available time for crew-to-ground consultation possibly to as little as one hour in a 24 hour period.”— Evidence report — Communication, Telemetry, and Data Constraints
“These limitations lead to a need for a highly robust, autonomous, and self-supported medical system…”— Evidence report — Communication, Telemetry, and Data Constraints

How ASTRA Health uses it

Motivation for ASTRA Health's on-board autonomy (understand and act locally) and for the delayed Earth-link simulator. The simulator's 3–22 min one-way delay comes from the team brief and is not derived from this report.

No threshold derived

Limitations

Approved for public release in May 2017; the HRR risk page (last published May 2025) may reflect a newer state of knowledge.
It describes needs and evidence for exploration medical capability; it does not approve ASTRA Health's checklists, which remain demonstration content.
The communication figures are cited by the report from earlier studies (Hamilton et al. 2008; Baisden et al. 2008).

Links and quotes verified against the official source on 2026-11-15.

Real scientific data · kept apart from the simulation

NASA OSDR dataset — real measurements

Real scientific data & evidence

Separated from ASTRA Health's simulated vital signs

Real serum biomarker data from four private astronauts of a 3-day low-Earth-orbit mission (SpaceX Inspiration4), published by NASA OSDR.
Only summary statistics per timepoint are shown; per-person values are not displayed.
Not used by the analysis engine, the alerts or the reports, and not comparable with the simulated heart rate, SpO₂ or temperature.
No reference range or clinical interpretation is applied to these values.
Verified on 2026-11-15: identical to a fresh OSDR download (SHA-256); all 252 values and 9 units cross-checked with the submitted results file; statistics confirmed by an independent implementation (docs/SCIENCE_VERIFICATION.md).

Repository: NASA Open Science Data Repository (OSDR)
Accession: OSD-575
Public release: 14-May-2024
Study title: SpaceX Inspiration4 Blood Serum Metabolic Panel and Immune/Cardiac Cytokine Arrays (Comprehensive Metabolic Panel and Multiplex)
Mission: SpaceX Inspiration4 (09/16/2021 – 09/18/2021)
File: LSDS-8_Multiplex_serum_cardiovascular_EvePanel_TRANSFORMED.csv
Folder: Immunoassay · ALSDA Transformed Files
SHA-256 (verbatim copy): fdba6c3ce45401c1…d9cfc75c
Retrieved on: 2026-11-15 · scripts/import-osdr.mjs
Publications: The Space Omics and Medical Atlas (SOMA) and international astronaut biobank (doi:10.1038/s41586-024-07639-y)Collection of Biospecimens from the Inspiration4 Mission Establishes the Standards for the Space Omics and Medical Atlas (SOMA) (doi:10.1038/s41467-024-48806-z)CAMbank: SST Field Processing v1 (doi:10.17504/protocols.io.81wgbxxo1lpk/v1)

4 crew members · 28 serum samples · 7 timepoints (L-92, L-44, L-3, R+1, R+45, R+82, R+194) · 9 analytes

α2-Macroglobulin — mean (line) and min–max range (band) per timepoint, ng/mL

Timepoint	n	Mean	Min	Max
L-92 pre	4	1,831,336	903,743	3,030,400
L-44 pre	4	639,410	531,434	734,243
L-3 pre	4	1,905,925	1,002,300	2,948,400
R+1 post	4	1,666,364	913,857	3,051,700
R+45 post	4	1,843,150	1,130,800	2,895,000
R+82 post	4	2,077,625	1,403,700	2,993,600
R+194 post	4	1,897,075	1,568,600	2,342,900

Unit: ng/mL (column token “nanogram_per_milliliter”). L = days before launch, R = days after return.

9 column(s) not displayed: Percent columns are not explained in the study metadata, so they are not displayed.

Import another OSDR file

Supported: OSDR multiplex “TRANSFORMED” tables (Sample Name + concentration columns), such as the OSD-575 cardiovascular or immune panels. The file is read only in this browser and never enters the mission simulation. To bundle a dataset with the app, run npm run osdr:import -- OSD-575.

AccessionChoose CSV file

Data & rules provenance

What is what in ASTRA Health

Content	Category	Source	Used by
Heart rate, SpO₂ and temperature streams, signal quality, dropouts	Simulated data	scripts/generate-scenarios.mjs (seeded) → src/data/scenarios/*.json	Monitoring, Analysis
Confirmation reading and ground acknowledgement	Simulated data	Scenario JSON and Earth-link simulator	Response, Earth Link
Demo reference ranges, caution bands, plausibility limits, analysis rules, reliability score	Demonstration rules	src/config/reference-ranges.ts, src/lib/analysis/ (status PROVISIONAL)	Analysis engine
Medical-support escalation rules and safety checklists	Demonstration rules	src/lib/response/escalation.ts, src/data/procedures.json	Response
Earth–Mars delay 3–22 min, 30 s transmission, 2 min ground handling	Demonstration rules	Team brief; src/lib/comms/	Earth Link
NASA HRP evidence reports — cardiovascular, hypoxia, medical capability	Real scientific data & evidence	humanresearchroadmap.nasa.gov · ntrs.nasa.gov · nasa.gov	Science & Limits (context only — no threshold derived)
NASA OSDR OSD-575 — Inspiration4 serum cardiovascular biomarker panel	Real scientific data & evidence	osdr.nasa.gov (imported verbatim by scripts/import-osdr.mjs)	Science & Limits (display only — never mixed with simulated vital signs)

NASA registry

Source for analysis thresholds

Pending confirmation

The evidence library and the OSDR dataset above are integrated as scientific context and real data, but none of them defines ASTRA Health's numeric limits. This registry is reserved for a NASA source of thresholds; it stays empty until Team ANGARIS confirms the official challenge statement, so every threshold remains a provisional demonstration value.

Name: pending team confirmation
Origin: pending team confirmation
URL / DOI: pending team confirmation
Version · accessed: pending team confirmation
Effective use in the app: pending team confirmation

Integration points

src/config/reference-ranges.ts — analysis thresholds (currently provisional placeholders)
src/data/procedures.json — demonstration safety checklists
src/lib/comms/delay.ts — Earth–Mars delay range (3–22 min per the team brief)

Values taken from the team brief

Earth–Mars one-way signal delay: Approximately 3 to 22 minutes per direction — ASTRA Health team brief (to be cross-checked against the confirmed NASA resource)

Read before the demo

Scientific limitations

All vital signs on the Monitoring, Analysis and Response pages are synthetic, generated by a seeded script. The only real measurements in the app are the NASA OSDR summaries on this page, which are kept separate from the simulation.
Reference ranges, caution bands and sensor rules are provisional placeholders chosen by the development team. They have not been validated clinically and are not derived from the NASA evidence library.
The NASA evidence library is cited as scientific context. Quotes are verbatim and linked; the official documents remain the authoritative source and may be updated by NASA.
The OSDR dataset comes from four private astronauts on a 3-day low-Earth-orbit mission; it is shown as summary statistics only and is not representative of long-duration Mars missions.
The analysis engine is deterministic and rule-based. It produces attention levels and data-reliability scores, never a diagnosis.
Procedures are illustrative safety checklists. They are not approved flight procedures and never include medication, treatment or clinical interventions.
Escalation rules only indicate when to involve the Crew Medical Officer and the ground flight surgeon. They are demonstration rules.
The Earth–Mars link is a simulation. The 3–22 min one-way range is a simplification from the team brief; real delay depends on planetary geometry and the link can be unavailable (e.g. near solar conjunction).
Ground acknowledgements are automatic placeholders. No real person reviews any message.
Only three scripted scenarios are covered. Real sensors exhibit many other artifacts and real physiology many other patterns.
The prototype has no authentication, persistence, encryption or medical-device quality controls.

PROVISIONAL

Demo reference ranges and sensor rules

PROVISIONAL

Demonstration placeholder values chosen by the development team. Not clinically validated. Pending confirmation of the official challenge statement and NASA resource.

Vital sign	Demo reference	Caution band	Plausibility limits	Max step / sample	Simulated sensor
Heart rate	50–100 bpm	40–120 bpm	25–230 bpm	30 bpm	Chest ECG patch (simulated)
Oxygen saturation	95–100 %	90–100 %	50–100 %	6 %	Finger pulse oximeter (simulated)
Body temperature	36.0–37.5 °C	35.5–38.0 °C	30.0–43.0 °C	0.6 °C	Skin temperature probe (simulated)

Persistence: 3 samples · sensor look-back: 10 samples · degraded quality < 60 % · poor quality < 40 %. Edit in src/config/reference-ranges.ts.

Demonstration scenarios

Simulated data provenance

Scenario 1 — Nominal monitoring
All simulated vital signs stay inside the demo reference ranges and all sensors report good signal quality. The system keeps monitoring and nothing needs to be done.
180 samples · 10 s interval · scripts/generate-scenarios.mjs · seed 1101
Scenario 2 — Simulated vital-sign deviation
Starting at the incident onset, simulated heart rate rises while oxygen saturation falls and temperature increases slightly. Sensor quality stays good, so the readings are consistent with each other.
180 samples · 10 s interval · scripts/generate-scenarios.mjs · seed 2202
Scenario 3 — Sensor fault / inconsistent reading
At the incident onset the simulated pulse oximeter starts reporting erratic, very low SpO₂ values with poor signal quality and dropouts, while heart rate and temperature stay steady. The pattern points to a sensor problem that the crew must confirm.
180 samples · 10 s interval · scripts/generate-scenarios.mjs · seed 3303

Transparency

AI Tools & Usage Disclosure

Team ANGARIS used AI-assisted tools, including Claude Code, Codex, and ChatGPT, as applicable, to support software development, code review, documentation, and presentation preparation.

The project’s concept, technical decisions, testing, and final validation are the responsibility of Team ANGARIS.

All physiological data presented in the prototype are simulated. ASTRA Health is an experimental demonstration and is not a clinically validated medical device.

The ASTRA Health logo (and the emblem cropped from it for the header and favicon) is an AI-generated image; the original file keeps its "AI-generated" label (public/brand/astra-health-logo.png). See AI_DISCLOSURE.md in the repository.

No AI model runs inside the application: all analysis is deterministic.